Predetermined (usually 100 ml) volume of blood is exposed to the same amount of ozone gas in a ozone resistant bottle and reinfuse to the patient by the same cubital vein. Major ozone therapy is the most reliable and effective method. It could be combined with other ozone administration routes. MAT is advised for 2-3 times per week for 12 sessions. Patients with uncontrolled diabetes, metobolic diseases, neurodegenerative diseases, patients who take chemotherapy, stroke patients could get benefit from MAT.
